Secreted protein acidic and rich in cysteine (SPARC) induces apoptosis of human brain vascular smooth muscle cells through regulating HK2 in intracranial aneurysm.

"Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"The authors declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Youth Science Fund Cultivation Grant Program of Shandong First Medical University (Shandong Academy of Medical Sciences) (No. 202201-106), the National Natural Science Foundation of Shandong Province (No. ZR2022MH263), Open Project of Provincial Key Laboratory of Brain Function Reconstruction in Shandong Province (No. 2020NGN004) and International Scientific Exchange Foundation of China (No. Z2018LSD001), the Basic Ability Enhancement Project of Young Teachers in Guangxi Zhuang Autonomous Region (No. 2021KY0089), and the Research Project of Guangxi Health and Family Planning Commission (No. Z20190651)."