Dysregulated iron homeostasis in dystrophin-deficient cardiomyocytes: correction by gene editing and pharmacological treatment.

"obtained datasets were deposited in public repository (geo repository: gse226170). a protocol of the sample preparation and detailed methodology are described in the supplementary data 2 3 for the ros level determination 150 000 hipsc-cm were seeded onto a geltrex(tm)-coated 24-well plate.; all other methods including western blot reverse transcription quantitative pcr immunofluorescent staining mea and reagents preparation are described in detail in the supplementary data 3 3 1 to unveil the molecular effects of dystrophin deficiency in hipsc-cm we took a proteomic and transcriptomic approach."

"Conflict of interest: None declared. This manuscript was handled by Deputy Editor Pasquale Maffia."

"Funding The work was supported by the MAESTRO grant [2018/30/A/NZ3/00412 to J.D.] funded by the National Science Centre. CISTEM MSCA RISE grant [Z/H20/0023 to J.D.] funded by H2020 programme supported the secondments of K.A. and J.D. Proteomic analysis has been performed in the frame of the JPND grant [UMO-2019/01/Y/NZ3/00012 to J.D. and M.K.], the iPSC culture and differentiation to CMs were additionally supported by the OPUS grant [#2019/35/B/NZ3/02817 to A.Ł.] from the National Science Centre. K.A. is supported by the L’Oréal for Women in Science Scholarship. G.M. and G.Y. contributions are supported by the Faculty of Biochemistry, Biophysics and Biotechnology at Jagiellonian University (Poland), under the Strategic Programme Excellence Initiative."