Vesicular HMGB1 release from neurons stressed with spreading depolarization enables confined inflammatory signaling to astrocytes.

"Declarations Ethics approval and consent to participateAnimal housing, care, and application of experimental procedures were all performed in accordance with institutional regulations as approved by the Hacettepe University Animal Ethics Committee (Approval numbers: 2017/10-5 and 2018/30-1). The experiments were carried out according to the Guide for the Care and Use of Laboratory Animals and reported in accordance with the ARRIVE guidelines. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was supported by the Hacettepe University Scientific Research Projects Coordination Unit under grant TSA-2017-14418 and by the Scientific and Technological Research Council of Turkey (TUBITAK) under grant 118S435. Turgay Dalkara’s work is also supported by the Turkish Academy of Sciences."