Tom70-regulated mitochondrial biogenesis via TFAM improves hypoxia-induced dysfunction of pulmonary vascular endothelial cells and alleviates hypoxic pulmonary hypertension.

"Declarations Ethics approval and consent to participateThe study was approved and supervised by the Medical Research Ethics Committee of the Fourth Military Medical University. All experiments were performed in accordance with the relevant guidelines and regulations. The animal protocol has been reviewed and approved by the Institutional Animal Care and Use Committee (IACUC), the Fourth Military Medical University, China. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This present study was funded by the National Nature Science Foundation of China (Grant Numbers 81700058, 82271510) and the Natural Science Foundation of Shaanxi, China (Grant Numbers 2023-JC-YB-669, 2022JM-488)."