Analysis of vector genome integrations in multicentric lymphoma after AAV gene therapy in a severe hemophilia A dog.

"Declaration of interests The authors declare no competing interests."

"The authors sincerely thank the owners of PC1 and PC9 for entrusting their pets to this research study. We also acknowledge research funding from 10.13039/100000050NIH/National Heart, Lung, and Blood Institute (HL158781 to V.R.A. and B.J.S.-J. and N01_7N92019D00041 to T.C.N.). L.V.G. is supported by the NIH-sponsored Hematology Research Training Program at the University of Pennsylvania (HL07439). This study was also supported in part by the Companion Animal Research Fund from the Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania School of Veterinary Medicine and the Institute for Translational Medicine and Therapeutics of the Perelman School of Medicine and the School of Veterinary Medicine at the University of Pennsylvania. Work in the Bushman laboratory was supported in part by P30AI045008, U01AI125051, R01CA241762, UM1AI164570, R01HL142791, R01HL160748, U19AI174998, and U19AI149680. We also thank the Penn Vet Comparative Pathology Core (CPC) for their help with tissue preparation and imaging. The Penn Vet CPC is supported by the 10.13039/100017006Abramson Cancer Center Support Grant (P30 CA016520). The Aperio Versa 200 Scanner used for whole-slide imaging was acquired thanks to a NIH Shared Instrumentation Grant (S10 OD123465-01A1). The Leica BOND RXm automated instrument for IHC was acquired through Penn Vet’s Institute for Infectious and Zoonotic Diseases Core Pilot Grant Opportunity 2022. The graphical abstract was created with BioRender."