Demonstrating the importance of porcine reproductive and respiratory syndrome virus papain-like protease 2 deubiquitinating activity in viral replication by structure-guided mutagenesis.

"plos publication stage vor-update-to-uncorrected-proof publication update 2023-12-28 data availability structure factors and coordinates for the prrsv plp2 and plp2-ub complexes have been deposited to the protein data bank (pdb) under pdb ids8ehn and 8eho.; data availability structure factors and coordinates for the prrsv plp2 and plp2-ub complexes have been deposited to the protein data bank (pdb) under pdb ids8ehn and 8eho.; structure factors and coordinates for the prrsv plp2 and plp2-ub complexes have been deposited to the pdb under pdb ids8ehn and 8eho respectively. data availability structure factors and coordinates for the prrsv plp2 and plp2-ub complexes have been deposited to the protein data bank (pdb) under pdb ids8ehn and 8eho"

"The authors have declared that no competing interests exist."

"BBE was supported by an NSERC PhD studentship. BLM is supported by NSERC grants RGPAS-2020-00012 and RGPIN-2020-05682. MK received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 952373. MK and BLM also received funding from MSD Animal Health, who assisted in conceptualizing the project. NSERC and the European Union’s Horizon 2020 research and innovation programme had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."