Cellular senescence contributes to mechanical ventilation-induced diaphragm dysfunction by upregulating p53 signalling pathways.

"data availability the datasets generated during the current study are available in the gene expression omnibus (geo) repository and are accessible through geo series accession number gsegse228739 ( https://www ncbi nlm nih gov/geo/query/acc cgi? data availability the datasets generated during the current study are available in the gene expression omnibus (geo) repository and are accessible through geo series accession number gsegse228739"

"Declarations Ethics approval and consent to participateAll experiment was reviewed and approved by the Ethics Committee of the Zhejiang University School of Medicine. The Ethical code for animal study is ZJU20220319. All methods are reported in accordance with ARRIVE guidelines (https://arriveguidelines.org) for the reporting of animal experiments. All methods were performed in accordance with the relevant guidelines and regulations. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by the National Natural Science Foundation of China (82070087) and the Natural Science Foundation of Zhejiang Province (GD22H019093)."