SNHG17 alters anaerobic glycolysis by resetting phosphorylation modification of PGK1 to foster pro-tumor macrophage formation in pancreatic ductal adenocarcinoma.

"all sequencing data generated in this study are deposited at the national omics data encyclopedia (node) with the accession code oep019554."

"Declarations Ethics approval and consent to participateSample collections were approved by Ethics Committee of Ruijin Hospital, Shanghai Jiaotong University School of Medicine (2021 Clinical Ethnics Review No.161). Also, the animal research was authorized by the Shanghai Municipal Science and Technology Commission of Shanghai, China (SYXK-2018–0027). The informed consents were obtained from patients or their guardians, as appropriate. Consent for publicationNot applicable. Competing interestsThere is no conflict of interest. Competing interests There is no conflict of interest."

"Funding This work was supported by National Nature Science Foundation of China (Grant No.82303294), Shanghai Sailing Program (Grant No. 23YF1435400), PostGraduate Innovation Fund of Interdiscipline and New Medicine from School of Medicine of Shanghai University and the Fundamental Research Funds for the Central Universities (No. YG2023QNA04)."