DELE1 haploinsufficiency causes resistance to mitochondrial stress-induced apoptosis in monosomy 5/del(5q) AML.

"mcc (matthews correlation coefficient) values reported in the table s4 were calculated using epcy [ https://github com/iric-soft/epcy v0 0 1] on expression data (tpm) comparing -5/del(5q) aml to other aml from the leucegene cohort. data availability sequencing data used in this manuscript are available at: https://www ncbi nlm nih gov/geo/query/acc cgi? acc=gse67040"

"mcc (matthews correlation coefficient) values reported in the table s4 were calculated using epcy [ https://github com/iric-soft/epcy v0 0 1] on expression data (tpm) comparing -5/del(5q) aml to other aml from the leucegene cohort."

"Competing interests The authors declare no competing interests."

"The authors wish to thank Muriel Draoui for project coordination. JFS was supported by an IVADO and Canada First Research Excellence Fund (Apogée/CFREF) and a Canadian Institutes of Health Research (CIHR) postdoctoral fellowships. This work was supported by the Government of Canada through Genome Canada and the Ministère de l'économie et de l’innovation du Québec through Génome Québec (ref. grant #4524 and grant #13528). JH holds a research chair from Industrielle-Alliance (Université de Montréal). BCLQ is supported by grants from the Cancer Research Network of the Fonds de recherche du Québec–Santé. RNA-Seq read mapping and transcript quantification were performed on the supercomputer Briaree from Université de Montréal, managed by Calcul Québec and Compute Canada. The operation of this supercomputer is funded by the Canada Foundation for Innovation (CFI), NanoQuébec, RMGA and the Fonds de recherche du Québec - Nature et technologies (FRQ-NT)."