Integrative analysis of purine metabolites and gut microbiota in patients with neuromyelitis optica spectrum disorders after mycophenolate mofetil treatment.

"data availability the raw sequence data from the fecal microbiota in this paper were uploaded to the sequence read archive (sra) data ( https://www ncbi nlm nih gov/sra ) under accession number prjna813001. data availability the raw sequence data from the fecal microbiota in this paper were uploaded to the sequence read archive (sra) data ( https://www ncbi nlm nih gov/sra ) under accession number prjna813001"

"Declarations Ethics approval and consent to participateAll procedures performed in studies involving human participants were in accordance with the ethical standards and with the Helsinki declaration. And this study was approved by the ethics Committee of the Third Affiliated Hospital of Sun Yat-sen University ([2020]02-016-01). Written informed consent was obtained from all of patients or their relatives and healthy controls (or their parent or legal guardian in the case of children under 18). Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by grants from the National Natural Science Foundation of China (81771300, 81971140), Natural Science Foundation of Guangdong Province (2020A1515010053) and the Guangdong Major Project of Basic and Applied Basic Research (2020B0301030007) ."