The 4-1BBζ costimulatory domain in chimeric antigen receptors enhances CD8+ T-cell functionality following T-cell receptor stimulation.

"Declarations Ethics approval and consent to participateSpecimens from healthy human donors were collected and individuals consented under ethics protocol X18-0050, Sydney Local Health District Ethics (Eastern Zone) Committee. Consent for publicationNot applicable. Competing interestsThe authors declare no conflicts of interest. Competing interests The authors declare no conflicts of interest."

"Funding GJC was the recipient of: the Royal Prince Alfred Cellular Immunotherapy Fellowship, funded by the Sydney Local Health District; NHMRC Postgraduate Scholarship Grant (#1169460); Postgraduate Fellowship from the Royal College of Pathologists of Australasia Foundation; Postgraduate Completion Scholarship in Immunotherapies for Treating Mesothelin-Positive Cancers (2021–2022) funded by CSR Ltd. JEJR was funded by the National Health and Medical Research Council Investigator Grant to JEJR #1177305, Cancer Council of NSW Pathways to a Cancer-Free Future (PW18-03) and Project Grant (RG20-07), and Tour de Cure Research Grant RSP-278-18/19. JEJR also received funding from the Li Ka-Shing Cell and Gene Therapy Initiative, CSR Limited, as well as an anonymous foundation."