Mimicking hypomethylation of FUS requires liquid-liquid phase separation to induce synaptic dysfunctions.

"Declarations Competing interestsThe authors declare that there are no competing financial interests associated with this work. Competing interests The authors declare that there are no competing financial interests associated with this work."

"S.C.K., S.J.M, M-D R. and K.C. were funded by the UK Dementia Research Institute which receives its funding from DRI LTD, funded by the UK Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK. Wellcome Trust Collaborative Award 203249/Z/16/Z to P.StGH and K.C. Canadian Institutes of Health Research (406915 Foundation Grant and Canadian Consortium on Neurodegeneration in Aging Grant), US Alzheimer Society Zenith Grant ZEN-18-529769, Alzheimer Society of Ontario Chair in Alzheimer’s Disease Research; National Institute of Aging (U01AG072572; R01AG070864 to P.StGH."