20(S)-ginsenoside Rg3 exerts anti-fibrotic effect after myocardial infarction by alleviation of fibroblasts proliferation and collagen deposition through TGFBR1 signaling pathways.

"Declaration of competing interest The authors declare that the study was performed without any commercial conflict."

"This study was supported by the 10.13039/501100001809National Natural Science Foundation of China (grant numbers 82274417, 81973645, 81774100), 10.13039/501100003453Natural Science Foundation of Guangdong Province (Nos. 2022A1515011630, 2021A1515220010), and Guangdong Basic and Applied Basic Research Foundation (No. 2022A1515110870). Honglin Xu: Conceptualization, Investigation, Methodology, Validation, Formal analysis, Writing original draft, Visualization; Haifeng Miao: Investigation, Methodology, Validation, Formal analysis, Visualization; Guanghong Chen: Investigation, Methodology, Validation, Formal analysis; Guoyong Zhang: Investigation, Methodology, Validation, Formal analysis; Yue Hua: Methodology, Validation, Formal analysis; Yuting Wu: Methodology, Validation, Formal analysis; Tong Xu: Methodology, Software, Validation; Xin Han: Methodology, Software, Validation; Changlei Hu: Methodology, Formal analysis; Mingjie Pang: Validation, Formal analysis; Leyi Tan: Data curation, Formal analysis; Bin Liu: Funding acquisition, Methodology, Project administration, Supervision, Validation; Yingchun Zhou: Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Validation. All authors agree to be accountable for all aspects of work ensuring integrity and accuracy."