Advanced structural brain aging in preclinical autosomal dominant Alzheimer disease.

"code used in this study is available at https://github com/peterrmillar/dianbrainage .; first dbn can be estimated quickly and automatically using a publicly-available python script which requires less intensive preprocessing and quality control [ ].; code used in this study is available at https://github com/peterrmillar/dianbrainage ."

"Declarations Ethics approval and consent to participateDIAN participants provided informed consent in accordance with the local institutional review boards of each participating site. DIAN study procedures have received ethics approval by the Human Research Protection Office at Washington University in St. Louis (MO, USA) and all of the participating sites. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This research was funded by grants from the National Institutes of Health (P01-AG026276, P01-AG03991, P30-AG066444, 5-R01-AG052550) and the BrightFocus Foundation (A2022014F), with generous support from the Paula and Rodger O. Riney Fund and the Daniel J. Brennan MD Fund. Data collection and sharing for this project was supported by The Dominantly Inherited Alzheimer Network (DIAN, U19-AG032438) funded by the National Institute on Aging (NIA), the Alzheimer’s Association (SG-20-690363-DIAN), the German Center for Neurodegenerative Diseases (DZNE), Raul Carrea Institute for Neurological Research (FLENI), Partial support by the Research and Development Grants for Dementia from Japan Agency for Medical Research and Development (AMED JP23dk0207066), and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), Spanish Institute of Health Carlos III (ISCIII), Canadian Institutes of Health Research (CIHR), Canadian Consortium of Neurodegeneration and Aging, Brain Canada Foundation, and Fonds de Recherche du Québec – Santé. JJLG’s research is supported by NIH-NIA (K01AG073526), the Alzheimer’s Association (AARFD-21-851415, SG-20-690363), the Foundation for Barnes-Jewish Hospital and the McDonnell Academy. JCM is funded by NIH grants # P30 AG066444; P01AG003991; P01AG026276; U19 AG032438; and U19 AG024904. Neither JCM nor his family owns stock or has equity interest (outside of mutual funds or other externally directed accounts) in any pharmaceutical or biotechnology company. RJP’s research is supported by NIH (R01 AG05255005, P01 AG00399139, R01 AG05456705, R01 AG05777705, P30 AG06644403, R01 AG07490901, R01 NS07532111, R01 AG05326704, U19 AG03243811, U19 AG03243811, U19 AG06970102, R01 NS09779906, R01 AG05867604, U19 AG024904-16, P30 AG06644404). RJP’s laboratory provides technical services to enable the examination of participants in clinical trials of ALS treatments supported by Biogen. Neither RJP nor his family owns stock or has equity interest (outside of mutual funds) in any pharmaceutical or biotechnology company. RFA is funded by Fleni, CONICET, NIH (DIAN subcontract), Alzheimer Association (LatamFINGER, DIAN and iLEADS), and he reports speaker and consulting fees from Novo Nordisk, Tecnofarma, Biogen, and Roche. GSD’s research is supported by NIH (K23AG064029, U01AG057195, U01NS120901, U19AG032438), the Alzheimer’s Association, and Chan Zuckerberg Initiative. He serves as a consultant for Parabon Nanolabs Inc, as a Topic Editor (Dementia) for DynaMed (EBSCO), and as the Clinical Director of the Anti-NMDA Receptor Encephalitis Foundation (Inc, Canada; uncompensated). He is the co-Project PI for a clinical trial in anti-NMDAR encephalitis, which receives support from Horizon Pharmaceuticals. He has developed educational materials for PeerView Media, Inc, and Continuing Education Inc. He owns stock in ANI pharmaceuticals. GSD’s institution has received support from Eli Lilly for GSD’s development and participation in an educational event promoting early diagnosis of symptomatic Alzheimer disease. JL reports speaker fees from Bayer Vital, Biogen, EISAI, TEVA and Roche, consulting fees from Axon Neuroscience, Biogen and EISAI, author fees from Thieme medical publishers and W. Kohlhammer GmbH medical publishers and is inventor in a patent “Oral Phenylbutyrate for Treatment of Human 4-Repeat Tauopathies” (EP 23 156 122.6) filed by LMU Munich. In addition, he reports compensation for serving as chief medical officer for MODAG GmbH, is beneficiary of the phantom share program of MODAG GmbH and is inventor in a patent “Pharmaceutical Composition and Methods of Use” (EP 22 159 408.8) filed by MODAG GmbH, all activities outside the submitted work. RJB is on the scientific advisory board of C2N Diagnostics and reports research support from Abbvie, Avid Radiopharmaceuticals, Biogen, Centene, Eisai, Eli Lilly and Company, Genentech, Hoffman-LaRoche, Janssen, and United Neuroscience."