Trioxidized cysteine in the aging proteome mimics the structural dynamics and interactome of phosphorylated serine.

"data availability statement all proteomics data generated in this study have been made publicly available in proteomexchange through the specialized repository pride with the identifier pxd037908. data s1.; data s2.; data s3.; data s4."

"the scripts created for the bioinformatic analyses performed have also been made publicly available through github: https://github com/joseasanchezmilan/tcys_project git ."

"CONFLICT OF INTEREST STATEMENT The authors declare that they have no competing interests with regard of the data and conclusions reported in this work. The interpretations provided are based on the obtained scientific data and are that of the authors and not necessarily that of the public bodies that funded the study."

"Support for this work was provided by the National Institute of Health/Instituto de Salud Carlos III‐ISCIII, Spain (PI22/00443 to X.G.‐P.), grant co‐funded by the European Union; the Ministry of Science and Innovation‐MCIN, Spain and the National Research Council/Agencia Estatal de Investigación‐AEI, Spain (PID2020‐114885RB‐C21 to A.S.) funded by MCIN/AEI/ 10.13039/501100011033; the MCIN with funds from the European Union NextGenerationEU (PRTR‐C17.I1) and from the Autonomous Community of Catalonia “Biotechnology Plan Applied to Health” [(EVBRAINTARGET‐Y7340‐ACPPCCOL007 to X.G.‐P. & A.S.) coordinated by the Institute for Bioengineering of Catalonia (IBEC)]; and the Diputació de Lleida, Spain (PIRS22/03 to X.G.‐P. & PIRS23/02 to A.S.). The Singapore National Medical Research Council (NMRC/OFIRG/0003/2016 to S.K.S.); Canadian Institutes of Health Research Tier1 Canada Research Chair (CRC‐2020‐00263 to S.K.S.); Canadian Institutes of Health Research Project Grant (PJT‐186091 to S.K.S.); The Natural Sciences and Engineering Research Council of Canada Discovery Grant (RGPIN‐2023‐04304 to S.K.S.); Canada Foundation for Innovation Grant (41454 and 44115 to S.K.S.); Ontario Research fund (to S.K.S.); and start‐up research grant from Brock University (to S.K.S.). J.A.S.M. acknowledges a predoctoral “Joan Oró” scholarship funded by the Catalan Research Council‐AGAUR (2023 FI‐1 00054); J.A.S.M. contributions have also been partially supported by “Ajuts al Talent en Investigació Biomèdica” from Diputació de Lleida, Spain. M.F.‐R. acknowledges a postdoctoral contract funded by “2022 Biotechnology Plan Applied to Health” (ACPPCCOL007) coordinated by IBEC. M.M. acknowledges a predoctoral scholarship (PRE2021‐097934) funded by MCIN/AEI/ 10.13039/501100011033 and by "FSE+". A.S. acknowledges a Ramón y Cajal program tenure track contract (RYC2021‐030946‐I) funded by MCIN/AEI/ 10.13039/501100011033 and by “European Union NextGenerationEU/PRTR”. X.G.‐P. acknowledges a Miguel Servet program tenure track contract (CP21/00096) of the ISCIII, awarded on the 2021 call under the Health Strategy Action, co‐funded by the European Union (FSE+). IRBLLEIDA, J.A.S.M., A.S. & X.G.‐P. are co‐funded by CERCA Program/Generalitat de Catalunya; X.G.‐P. is member of the ExoPsyCog Consortium, funded by IKUR‐Neurobiosciences—Basque Government."