A distinct isoform of lymphoid enhancer binding factor 1 (LEF1) epigenetically restricts EBV reactivation to maintain viral latency.

"plos publication stage vor-update-to-uncorrected-proof publication update 2024-01-03 data availability the data that support the lef1 binding studies have been deposited at gene expression omnibus (gse245534).; data availability the data that support the lef1 binding studies have been deposited at gene expression omnibus (gse245534).; cut-and-run sequencing data is available at gene expression omnibus (accession number gse245534). raw microscope image files were deposited in dryad (doi: 10 5061/dryad 9zw3r22n8 ) all other relevant data are within the manuscript or included as supporting information .; raw microscope image files were deposited in dryad (doi: 10 5061/dryad 9zw3r22n8 ) all other relevant data are within the manuscript or included as supporting information .; raw microscope image files were deposited in dryad [ ] https://doi org/10 5061/dryad 9zw3r22n8 total cellular rna was isolated via stat-60 homogenization and chloroform/isopropanol isolation. the gene annotation for the ebv akata genome (kc 207813) is shown on the bottom track (tif) click here for additional data file s1 table (docx) click here for additional data file s2 table (docx) click here for additional data file s3 table (docx) click here for additional data file s4 table (docx) click here for additional data file s1 data each worksheet is labeled according to the respective figure panel (xlsx) click here for additional data file s2 data the files are arranged in folders labeled according to the respective figure (zip) click here for additional data file. xlsx) click here for additional data file s2 data availability the data that support the lef1 binding studies have been deposited at gene expression omnibus (gse245534"

"The authors have declared that no competing interests exist."

"This research was supported by the following NIH grants: R01DE025565 from the National Institute of Dental and Craniofacial Research and P20GM134974 (Center for Applied Immunology and Pathological Processes) from the National Institute of General Medical Sciences to RSS, a Carroll Feist predoctoral fellowship from the LSU Health-Shreveport Feist-Weiller Cancer Center to BJHW, and a predoctoral fellowship from the LSU Center for Emerging Viral Threats to DLS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."