Establishment and Comprehensive Characterization of a Novel Preclinical Platform of Metastatic Retinoblastoma for Therapeutic Developments.

"Disclosure: S. Zugbi, None; R. Aschero, None; D. Ganiewich, None; M.B. Cancela, None; U. Winter, None; D. Ottaviani, None; C. Sampor, None; M. Dinardi, None; A.V. Torbidoni, None; M. Mena, None; L. Balaguer-Lluna, None; G. Lamas, None; M. Sgroi, None; E. Lagomarsino, None; F. Lubieniecki, None; A. Fandiño, None; F. Radvanyi, None; D.H. Abramson, None; O. Podhajcer, None; A.S. Llera, None; E.G. Cafferata, None; G. Chantada, None; A.M. Carcaboso, None; P. Schaiquevich, None"

"Supported by the National Agency for Science and Technology Promotion (PIDC 2014-0043); Fundación Leo Messi; Instituto Oncológico Henry Moore, Argentina; Fundación Natalie Dafne Flexer de Ayuda al Niño con Cancer, Argentina; Amazon Web Services Cloud Credits for Research; Foundation Nelia et Amadeo Barletta, Switzerland; Fund for Ophthalmic Knowledge, New York, NY, USA. Author Contributions: Conceptualization: FR, DHA, ASLL, OP, GCH, AMC, PS.; Methodology: SZ, RA, DG, UW, DO, ASLL, OP, EGC, AMC, PS; Cell line establishment and phenotypical characterization: SZ, RA, MBC, UW, AT; Animal studies: SZ, RA, MBC, UW, AT, EGC, AMC; Histopathological and immunocytological evaluations: RA, GL, FL; Genomic analysis: DG, MM, ASLL, FR; Patient treatment and follow-up: CS, EL, MS, AF; Data analysis: SZ, RA, DG, MBC, UW, ASLL, PS; Writing: SZ, ASLL, PS; Funding acquisition: DHA, GCH, PS. All authors significantly contributed to the design of the study, data interpretation, writing and editing and agreed to the published version of the manuscript."