Elevated FBXL6 activates both wild-type KRAS and mutant KRAS^G12D and drives HCC tumorigenesis via the ERK/mTOR/PRELID2/ROS axis in mice.

"the mass spectrometry proteomics data have been deposited to the proteomexchange consortium ( http://proteomecentral proteomexchange org ) via the pride partner repository with the dataset identifier pxd032357."

"Declarations Ethics approval and consent to participateThis study was approved by the Ethics Committee of Southwest Hospital of Army Medical University. HCC samples were obtained from patients in Southwest Hospital of Army Medical University after obtaining signed informed consent (KY2020127). All animal experiments were approved by the Institutional Animal Care and Use Committee (IACUC) of Army Medical University and complied with all relevant ethical regulations (AMUWEC2020022). Consent for publicationNot applicable. Competing interestsThe authors declare no conflicts of interest. Competing interests The authors declare no conflicts of interest."

"Funding This work was supported by the National Natural Science Foundation of China (82370631), the Talent Foundations from Army Medical University (4174C6), and the Chongqing Government (CQYC20220303727) to Xie CM, and the National Natural Science Foundation of China (31900449) to Xiong HJ."