Regulation of human neutrophil IL-1β secretion induced by Escherichia coli O157:H7 responsible for hemolytic uremic syndrome.

"statistical significance was defined as *p<0 05; **p<0 01; ***p<0 001; ****p<0 0001; ns: non-significant s1 data excel spreadsheet containing on separate sheets the underlying numerical data and statistical analysis for all the figures in this work (xlsx) click here for additional data file s1 fig neutrophils were cultured for 3 5 h at 37? xlsx) click here for additional data file s1"

"JC is inventor of a patent related to Ecotin. The patent “Immunomodulating and immunostimulating polypeptides for drug-delivery” was filled on February 8, 2019 by the authors’ National Research Council (CONICET) and the University of San Martin (UNSAM) in the United States patent and trademark Office (US2021009371), the European patent office (PCT/IB2019/051026, EP3749364), the China National intellectual property administration (CN111936166), and the National Institute of Intellectual Property from Argentina (AR114683). The filing of the patent did not have any role in experimental design, data collection and analysis, decision to publish, or preparation of this manuscript. The authors have no financial conflicts of interest."

"This work was supported by grants from Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación, Ministerio de Ciencia, Tecnología e Innovación, Argentina https://www.argentina.gob.ar/ciencia/agencia/laagencia (PICT-2018-02338 and PICT2020-4010 to AST, and PICT2020-2472 to FS); Wellcome Trust https://wellcome.org/ (221859/Z/20/Z to JGG), and Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. https://www.conicet.gov.ar/ (PIBAA 28720210100978CO to FS). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript."