SNP (A > G - rs13057211) but not GT(n) polymorphism in HMOX-1 promotor gene is associated with COVID-19 mortality.

"sd while abnormally distributed variables were expressed as median (range) crp: c-reactive protein pct: procalcitonin ldh: lactate dehydrogenase and hmox-1: hemoxygenase enzyme ? : t-test + : mann-whitney test ? : pearson ?: levene's test significant p -value: less than 0 05 interestingly when the sequence of each case included in the study was examined thoroughly a (a > g) snp (rs13057211) in the gt(n) region of hmox-1 promoter gene was found (fig 4 ) fig 4 sequence results and agarose gel electrophoresis of 2 representative samples from the studies cohort the upper panel (1) shows the sequence of the wild type a (genbank s58267) while (b) shows the the (a > g) snp (rs13057211) the lower panel (2) shows agarose gel electrophoresis of the amplified segment (~ 80 bp) of hmox-1 promoter gene in some samples the amplicon (thick arrow pointing at the 80 bp fragment) was subsequently purified and sequenced.; data availability the datasets generated during the current study are available in the bioproject: repository accession: prjna1015194. data availability the datasets generated during the current study are available in the bioproject: repository accession: prjna1015194"

"Declarations Ethics approval and consent to participateThis study was approved by the Ethical Committee of the Medical Research Institute, Alexandria University (IORG#: 0008812). Informed Consent of patients/guardians was taken before enrolment in the current study and patients/guardians consented that the research data will be subjected to publication in peer reviewed journals. Consent for publicationAll data and materials used to generate this manuscript are available from the corresponding author for review or if needed in future meta-analysis studies. Competing interestsThe authors declare no conflict of interest. Competing interests The authors declare no conflict of interest."

"Funding Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB). This work was carried out using the Chemical Pathology Department Research fund (Fund No.25642; Medical Research Institute) that is allocated by Alexandria University of Egypt."