Astrocytes control hippocampal synaptic plasticity through the vesicular-dependent release of D-serine.

"Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by project funding from Fundação para a Ciência e para a Tecnologia (FCT) to AMS (PTDC/MEDFAR/30933/2017) and SHV (PTDC/BTM-SAL/32147/2017). This project has received funding from H2020-WIDESPREAD-05- 2017-Twinning (EpiEpinet) under grant agreement No. 952455 and the ISN Career Development Grant 2021 to SHV The authors are grateful to Professor Philip Haydon and Dr. João Oliveira for sharing the dn-SNARE mouse lines. The authors acknowledge the Fundação para a Ciência e Tecnologia (FCT) post-doctoral fellowship (PTDC/BTM-SAL/32147/2017-IMM/CT/35-2018) to FFR. "