Collaborative effect of Csnk1a1 haploinsufficiency and mutant p53 in Myc induction can promote leukemic transformation.

"rna sequencing data have been deposited in the zenodo database (doi:10 5281/zenodo 10474240)."

"Conflict-of-interest disclosure: Y.B.-N. is a consultant for Edgewood Oncology, a company advancing A51 clinical development for AML/high-risk MDS. The remaining authors declare no competing financial interests."

"This work was supported by a KWF Kankerbestrijding Young Investigator grant (11031/2017–1, Bas Mulder Award, Dutch Cancer Foundation), grants of the 10.13039/501100001659German Research Foundation (CRU344-4288578857858; CRU344-17911533), a grant from the 10.13039/501100000781European Research Council (deFIBER; ERC-StG 757339), and a ZonMW VIDI 09150172110021 (R.K.S.). U.S.A.S. was supported by a research fellowship by the IMF University of Münster (ST521701) and by a research fellowship from the German Research Foundation (STA 1648/1-1). This work was further supported by a grant of the José Carreras Leukemia Foundation (R.K.S.). H.F.E.G. is supported by a Gilead Research Scholar Award in Oncology/Hematology, a ZonMW VENI grant, a grant of the German Research Foundation (CRU344 - GL 1093/1-2), and an Erasmus Medical Center Fellowship."