Impact of Preoperative Sleep Disturbances on Postoperative Delirium in Patients with Intracranial Tumors: A Prospective, Observational, Cohort Study.

"Disclosure The authors report no conflicts of interest in this work."

"This research was supported by the Application and Evaluation of Active Health Cloud Platform in China, National Key Research and Development Program of China (2018YFC2000704)."

"This prospective, observational, cohort study was conducted at Sanbo Brain Hospital, Capital Medical University. Ethical approval was obtained from the institutional ethics committee (SBNK-YJ-2022-011-01), and the trial was registered on the Chinese Clinical Trial Registry (ChiCTR2200059425). Patients (≥45 years) undergoing elective craniotomy for intracranial tumors from May 2022 to September 2022 were screened for eligibility. The patient who met one of the following criteria was excluded: (1) history of delirium, cognitive dysfunction, or psychosis; (2) history of stroke; (3) American Society of Anesthesiologists physical status classification > II; (4) having dissemination and distant metastasis; (5) unable to complete assessments due to various reasons. Written informed consent was obtained from all recruited patients or their legal representatives of the study."