Risk of infectious adverse events of venetoclax therapy for hematologic malignancies: a systematic review and meta-analysis of RCTs.

"Conflict-of-interest disclosure: M.P.C. reports operating grants from the Canadian Institutes of Health Research during the conduct of the study and salary support from the Fonds de Recherche du Québec – Santé, both unrelated to this work; personal fees from GEn1E Lifesciences and Nomic Bio as a member of the scientific advisory board; personal fees from AstraZeneca as a scientific consultant; research support from Cidara Therapeutics, Scynexis, Inc, and Amplyx Pharmaceutics during the conduct of the study but outside the submitted work; is the cofounder of Kanvas Biosciences Inc and owns equity in the company; and has pending patents, including: (1) methods for detecting tissue damage, graft-versus-host disease, and infections using cell-free DNA profiling, (2) methods for assessing the severity and progression of severe acute respiratory syndrome coronavirus 2 infections using cell-free DNA pending, and (3) rapid identification of antimicrobial resistance and other microbial phenotypes using highly multiplexed fluorescence in situ hybridization. M. Sebag is on the advisory boards of Janssen, Pfizer, Amgen, Novartis, Gilead, Bristol Myers Squibb, Focus Therapeutics, and Sanofi, and reports funding from the Canadian Institutes of Health Research and Janssen Pharmaceuticals. E.G.M. and T.C.L. have operating grants from the Canadian Institutes of Health Research and receive salary support from the Fonds de Recherche du Québec – Santé outside of this work. The remaning authors declare no competing financial interests."

"This work had no sources of funding."

"This systematic review and meta-analysis adhered to a protocol registered a priori on the International Prospective Register of Systematic Reviews (PROSPERO) (CRD42021259416) and followed the guidelines from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), and the Cochrane Handbook for Systematic Reviews of Interventions."