A modelling study to dissect the potential role of voltage-gated ion channels in activity-dependent conduction velocity changes as identified in small fiber neuropathy patients.

"the code of the model can be accessed at github ( )."

"Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision."

"The author(s) declare financial support was received for the research, authorship, and/or publication of this article. AM ans AL are funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 368482240/GRK2416. JT is supported by the Center for Neuroplasticity and Pain is supported by the Danish National Research Foundation (DNRF121). BN is supported by a grant from the Interdisciplinary Center for Clinical Research within the Faculty of Medicine at the RWTH Aachen University, DFG NA 9707/1. This work was funded by the Deutsche Forschungsgemeinschaft German Research Foundation LA 2740/3–1, 363055819/GRK2415 Mechanobiology of 3D epithelial tissues (ME3T). AL, BN and MD are supported by a grant from the Interdisciplinary Center for Clinical Research within the Faculty of Medicine at the RWTH Aachen University (IZKF TN1-1/IA 532001, IZKF TN1-1IA 532002, IZKF TN1-6/IA 532006, and IZKF TN1-9/IA 532009)."