Synergy of polymyxin B and minocycline against KPC-3- and OXA-48-producing Klebsiella pneumoniae in dynamic time-kill experiments: agreement with in silico predictions.

"raw data from sequencing are deposited in the ncbi sequence read archive under bioproject accession numbers prjna947381 (aru705) and prjna957334 (aru613)."

"Transparency declarations: All authors declare no conflicts of interest.: Author contributionsA.O., C.Z., T.T., P.L., L.E.F. and E.I.N. conceptualized and designed the study. C.M. improved the dynamic model and A.O. performed the in vitro experiments. C.Z. performed in silico predictions and calculations on dosing in the dynamic model, under the supervision of E.I.N. and L.E.F. A.O., C.Z., T.T., P.L., L.E.F. and E.I.N. analysed and interpreted the data. A.O., C.Z., T.T. and P.L. drafted the manuscript. All authors contributed to the revision and have approved the final version of the manuscript."

"Funding This study was funded by the Swedish Research Council (grant no. 2019-05911 and 2020-02320 to T.T., grant no. 2018-03296 to L.E.F.), and Vinnova (grant no. 2021-02699 to T.T.)."