Optimal blood tau species for the detection of Alzheimer's disease neuropathology: an immunoprecipitation mass spectrometry and autopsy study.

"Declarations Conflict of interestHZ has served at scientific advisory boards and/or as a consultant for Abbvie, Acumen, Alector, Alzinova, ALZPath, Annexon, Apellis, Artery Therapeutics, AZTherapies, Cognito Therapeutics, CogRx, Denali, Eisai, Nervgen, Novo Nordisk, Optoceutics, Passage Bio, Pinteon Therapeutics, Prothena, Red Abbey Labs, reMYND, Roche, Samumed, Siemens Healthineers, Triplet Therapeutics, and Wave, has given lectures in symposia sponsored by Cellectricon, Fujirebio, Alzecure, Biogen, and Roche, and is a co-founder of Brain Biomarker Solutions in Gothenburg AB (BBS), which is a part of the GU Ventures Incubator Program (outside submitted work). KB has served as a consultant, at advisory boards, or at data monitoring committees for Abcam, Axon, BioArctic, Biogen, JOMDD/Shimadzu. Julius Clinical, Lilly, MagQu, Novartis, Ono Pharma, Pharmatrophix, Prothena, Roche Diagnostics, and Siemens Healthineers, and is a co-founder of Brain Biomarker Solutions in Gothenburg AB (BBS), which is a part of the GU Ventures Incubator Program, outside the work presented in this paper. PRN participated in Advisory Board for Roche, Novo Nordics and Cerveau (outside submitted work). Andrew E. Budson has served on a consultant or on advisory boards for Sage Pharmaceuticals and Cognito Therapeutics and has received grant monies from Biogen, Bristol Myers Squibb, and Cyclerion. He receives publishing royalties from Elsevier and Oxford University Press. Rhoda Au serves on the scientific advisory board of Signant Health, as consultant to Biogen and has given a lecture in a symposia sponsored by Eisai. Robert A. Stern has served as a consultant to Biogen and Lundbeck. He receives royalties for published neuropsychological tests from Psychological Assessment Resources, Inc. MLA has received honorarium from the Michael J Fox Foundation for services unrelated to this study. He also receives royalties from Oxford University Press. The other authors declare no competing interests. Conflict of interest HZ has served at scientific advisory boards and/or as a consultant for Abbvie, Acumen, Alector, Alzinova, ALZPath, Annexon, Apellis, Artery Therapeutics, AZTherapies, Cognito Therapeutics, CogRx, Denali, Eisai, Nervgen, Novo Nordisk, Optoceutics, Passage Bio, Pinteon Therapeutics, Prothena, Red Abbey Labs, reMYND, Roche, Samumed, Siemens Healthineers, Triplet Therapeutics, and Wave, has given lectures in symposia sponsored by Cellectricon, Fujirebio, Alzecure, Biogen, and Roche, and is a co-founder of Brain Biomarker Solutions in Gothenburg AB (BBS), which is a part of the GU Ventures Incubator Program (outside submitted work). KB has served as a consultant, at advisory boards, or at data monitoring committees for Abcam, Axon, BioArctic, Biogen, JOMDD/Shimadzu. Julius Clinical, Lilly, MagQu, Novartis, Ono Pharma, Pharmatrophix, Prothena, Roche Diagnostics, and Siemens Healthineers, and is a co-founder of Brain Biomarker Solutions in Gothenburg AB (BBS), which is a part of the GU Ventures Incubator Program, outside the work presented in this paper. PRN participated in Advisory Board for Roche, Novo Nordics and Cerveau (outside submitted work). Andrew E. Budson has served on a consultant or on advisory boards for Sage Pharmaceuticals and Cognito Therapeutics and has received grant monies from Biogen, Bristol Myers Squibb, and Cyclerion. He receives publishing royalties from Elsevier and Oxford University Press. Rhoda Au serves on the scientific advisory board of Signant Health, as consultant to Biogen and has given a lecture in a symposia sponsored by Eisai. Robert A. Stern has served as a consultant to Biogen and Lundbeck. He receives royalties for published neuropsychological tests from Psychological Assessment Resources, Inc. MLA has received honorarium from the Michael J Fox Foundation for services unrelated to this study. He also receives royalties from Oxford University Press. The other authors declare no competing interests."

"Funding Open access funding provided by University of Gothenburg. This work is supported by the NIA (P30AG072978), NINDS (U54NS115266, RF1NS132290), and through the BU-CTSI Grant Number 1UL1TR001430. LMG is supported by the Brightfocus Foundation (A2022015F), the Swedish Dementia Foundation, Gun and Bertil Stohnes Foundation, Åhlén-stifelsen, Alzheimerfonden (AF-968621) and Gamla Tjänarinnor Foundation. Michael L. Alosco is supported by the NINDS (K23NS102399). Thomas K. Karikari was funded by the Swedish Research Council (Vetenskåpradet), the Alzheimer’s Association Research Fellowship (#850325), the BrightFocus Foundation (#A2020812F), the International Society for Neurochemistry’s Career Development Grant, the Swedish Alzheimer Foundation (Alzheimerfonden; #AF-930627), the Swedish Brain Foundation (Hjärnfonden; #FO2020-0240), the Swedish Dementia Foundation (Demensförbundet), the Swedish Parkinson Foundation (Parkinsonfonden), Gamla Tjänarinnor Foundation, the Aina (Ann) Wallströms and Mary-Ann Sjöbloms Foundation, the Agneta Prytz-Folkes & Gösta Folkes Foundation (#2020-00124), the Gun and Bertil Stohnes Foundation, and the Anna Lisa and Brother Björnsson’s Foundation. Kaj Blennow is supported by the Swedish Research Council (#2017-00915), the Alzheimer Drug Discovery Foundation (ADDF), USA (#RDAPB-201809-2016615), the Swedish Alzheimer Foundation (#AF-742881), Hjärnfonden, Sweden (#FO2017-0243), the Swedish state under the agreement between the Swedish government and the County Councils, the ALF-agreement (#ALFGBG-715986), the European Union Joint Program for Neurodegenerative Disorders (JPND2019-466-236), the National Institute of Health (NIH), USA, (grant #1R01AG068398-01), and the Alzheimer’s Association 2021 Zenith Award (ZEN-21-848495). Henrik Zetterberg is a Wallenberg Scholar supported by grants from the Swedish Research Council (#2022-01018 and #2019-02397), the European Union’s Horizon Europe research and innovation programme under grant agreement No 101053962, Swedish State Support for Clinical Research (#ALFGBG-71320), the Alzheimer Drug Discovery Foundation (ADDF), USA (#201809-2016862), the AD Strategic Fund and the Alzheimer's Association (#ADSF-21-831376-C, #ADSF-21-831381-C, and #ADSF-21-831377-C), the Bluefield Project, the Olav Thon Foundation, the Erling-Persson Family Foundation, Stiftelsen för Gamla Tjänarinnor, Hjärnfonden, Sweden (#FO2022-0270), the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska–Curie grant agreement No 860197 (MIRIADE), the European Union Joint Programme—Neurodegenerative Disease Research (JPND2021-00694), the National Institute for Health and Care Research University College London Hospitals Biomedical Research Centre, and the UK Dementia Research Institute at UCL (UKDRI-1003). Andrew E. Budson is supported by a Veterans Affairs Merit Award (CX001698) and National Institutes of Health grant P30 (AG072978). Hugo J. Aparicio is supported by an American Academy of Neurology Career Development Award, Alzheimer’s Association (AARGD-20-685362), and National Institutes of Health (R01AG066524, NS017950, L30 NS093634). Katherine Turk is supported by the United States Department of Veterans Affairs, (#IK2 CX002065). Rhoda Au is supported by the NIA (AG062109, AG063635, AG068753). Thor Stein is supported by the United States Department of Veterans Affairs Merit Award (I01-BX005933). Hugo J. Aparicio is supported by an American Academy of Neurology Career Development Award, Alzheimer’s Association Research Grant (AARGD-20-685362), and National Institutes of Health (R01AG066524). Sponsor: There is no sponsor."