A Meta-Analysis of the Antidepressant Responses in Pivotal Trials on Esketamine Nasal Spray and Atypical Antipsychotics.

"Disclosure Dr Lien Wang was a full time employee of Jassen Research and Development during the donduct of the study. Dr Xiaowei Chen is a full time employee of Janssen Research & Development and stockholder of Johnson & Johnson, outside the submitted work. Dr Heidi De Smedt is a full time employee of Jassen Research & Development and stockholder of Johnson & Johnson, outside the submitted work. Dr Xiaojing Gu was an employee of Johnson & Johnson China (Inv), outside the submitted work. Dr Vanina Popova is a full-time Employee of Janssen Research & Development, Shareholder of J&J Stock, outside the submitted work. Dr Dong-Jing Fu reports I’m a full time employee of Janssen Research & Development, LLC and stockholder of Johnson&Johnson. Dr Carla Canuso Full-time employee of Janssen Research & Development, Shareholder in Johnson & Johnson, outside the submitted work. Dr Wayne Drevets is a full time employee of Janssen Research & Development, of Johnson & Johnson, outside the submitted work; In addition, Dr Wayne Drevets has a patent Compositions and Methods for the treatment of depression pending to Johnson & Johnson; and I own equity in Johnson & Johnson. Dr Guang Chen was an employee of Janssen, during the conduct of the study. The authors report no other conflicts of interest in this work. All authors participated in the original design of the studies (LW, XC, GC), monitoring of data quality (LW, XC, XG, GC) and contributed to the data interpretation (LW, XC, XG, GC), development and review of this manuscript (all authors) and confirm that they have read the journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. All authors meet ICMJE criteria and all those who fulfilled those criteria are listed as authors. All authors had access to the study data, provided direction and comments on the manuscript, made the final decision about where to publish these data and approved submission to this journal. None of the authors had concerns about the validity of the study or competing interests which would have created a bias in the reporting of the results and conclusion."

"Authors thank study participants, without whom this study would never have been accomplished, and all the investigators, their medical, nursing and laboratory staff for their participation in these studies. Writing and editorial support were provided by Colleen Elliott, PhD of CME Sciences, LLC, and funded by Janssen Pharmaceuticals, Inc."