The DNA repair enzyme, aprataxin, plays a role in innate immune signaling.

"data has been submitted to geo with the accession number (gse245766) 4 9 in array express an additional study was identified with data complementary to this study using key search terms 'aptx' 'ataxia' and 'cgas-sting'.; original rna-seq datasets are available in the publicly accessible repository gene expression omnibus (geo) and can be found at the following link https://www ncbi nlm nih gov/geo/query/acc cgi accession number gse245766.; existing datasets are available in the publicly accessible repository biostudies (formerly known as array express) at accession number e-geod-124412."

"Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor KF declared a shared affiliation with the authors HM, MA, LR, and VB at the time of review."

"The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Novo Nordisk Foundation (NNF17OC0027812)."