ABCB1 overexpression through locus amplification represents an actionable target to combat paclitaxel resistance in pancreatic cancer cells.

"the ms proteomics data have been deposited to the proteomexchange consortium via pride (accession number pxd040930).; raw rna-sequencing data have been deposited on geo database under accession number gse228106.; availability of data and materials the dataset generated by rna-seq data for this study is available at gene expression omnibus (geo) database with accession number gse228106 and are available at the following url: https://www ncbi nlm nih gov/geo/query/acc cgi?; the mass spectrometry proteomics data have been deposited to the proteomexchange consortium via pride repository with the dataset identifier pxd040930 and 10 6019/pxd040930. availability of data and materials the dataset generated by rna-seq data for this study is available at gene expression omnibus (geo) database with accession number gse228106"

"Declarations Ethics approval and consent to participateAll specimens were obtained after patient’s written consent approved by the Ethics Committee of “Area Vasta Emilia Nord” (protocol code 12003—17/03/2021). Consent for publicationNot applicable. Competing interestsThe authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Competing interests The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."

"Funding E.G, E.H.J.D, T. S, A.G. and C.B. were supported by the Dutch Cancer Society (KWF Research Grant # 11957). E.H.J.D. was supported by Dutch Research Council (NWO; Science-XL grant 2019.022). G.M., and E.G. were supported by Italian Association of Cancer Research (AIRC, IG-grant) and by the Cancer Center Amsterdam Foundation (Proof-of-concept grant). L.A.M.D. and A.B. acknowledge support of the Fondazione Pisana per la Scienza ONLUS, under the project entitled “Precision Exosome Analysis for Early Diagnosis of Pancreatic Adenocarcinoma”. I.G. and E.G. were supported by the European organization for Research and Treatment of Cancer (EORTC GI Group’s Young Investigators grant)."