Fibroblast-derived extracellular vesicles as trackable efficient transporters of an experimental nanodrug with fibrotic heart and lung targeting.

"Competing Interests: The authors have declared that no competing interest exists."

"This work was partially supported by Agencia Estatal de Investigación, Spain PID2021-125702OB-I00; RTI2018-095214-B-I00). A.L.C. acknowledges support by the European Research Council grant ERC-CoG-648071-ProNANO; the Agencia Estatal de Investigación Grant PDC2021-120957-I00 funded by MCIN/AEI/ 10.13039/501100011033 and by the “European Union NextGenerationEU/PRTR” and Grant PID2019-111649RB-I00-ProTools funded by MCIN/AEI/ 10.13039/501100011033; and the Basque Government (RIS3-2019222005). G.G. thanks the financial support of “la Caixa” Foundation (ID100010434, fellowship: LCF/BQ/DI20/11780020). This work was performed under the Maria de Maeztu Units of Excellence Program from the Spanish State Research Agency - Grant No. MDM-2017-0720 (CIC biomaGUNE). We thank Dr. L Martin-Jaular, and the Institut Curie EV platform, for helpful discussion. We thank Dr. S Mobini and Dr. M.U. González for their collaboration with the tracking analysis studies. We express our gratitude to Dr. V Gabarra for her valuable advice and assistance in finalizing the text."