Hyperbaric oxygen augments susceptibility to <i>C. difficile</i> infection by impairing gut microbiota ability to stimulate the HIF-1α-IL-22 axis in ILC3.

"functional abundances were predicted using phylogenetic investigation of communities by reconstruction of unobserved states (picrust2) and visualized using the r package ggpicrust2 16s sequencing data were deposited in the ncbi bioproject: prjna900580.; in particular 16s sequencing data have been deposited in the ncbi bioproject: prjna900580. data availability statement all the relevant data supporting these findings are available in this report. in particular 16s sequencing data have been deposited in the ncbi bioproject: prjna900580"

"Disclosure statement No potential conflict of interest was reported by the author(s)."

"Author contributions: JLF and MARV contributed substantially to the conception of the work. All authors substantially contributed to the acquisition, analysis, and interpretation of data for the manuscript and critically reviewed the manuscript for important intellectual content. JLF, LPP, and HCA performed key experiments. All authors approved the final version of this manuscript and agreed to be accountable for all aspects of the work, ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Funding acquisition and resources were provided by the SG, MC and MARV. MARV supervised this study."