Enhanced renal clearance impacts levetiracetam concentrations in patients with traumatic brain injury with and without augmented renal clearance.

"Declarations Ethical approval and consent to participateThe study received IRB approval from the respective institutions. (IRB #150114-University of North Carolina at Chapel Hill Institutional Review Board and the Office of Human Research Ethics; IRB#15-0343-F6A-Univeristy of Kentucky Human Research/Institutional Review Board). and performed per the amended Declaration of Helsinki. Written informed consent, which was approved by local institutional review boards, were obtained from all study participants or legal representative as appropriate. The trial was registered à priori in clinicaltrials.gov (NCT02437838). Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This study was supported through a multi-institutional CTSA award (MCTSA005). The project described was also supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1TR001998.The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH."

"Clinical trial registration This study was registered at cliicaltrials.gov (NCT02437838) Registered on 08/05/2015, https://clinicaltrials.gov/ct2/show/NCT02437838."