Partial loss of Sorting Nexin 27 resembles age- and Down syndrome-associated T cell dysfunctions.

"Declarations Ethics approval and consent to participateNot applicable. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. CR-R held a predoctoral fellow of the Álvaro Entrecanales and Jérôme Lejeune Foundations. NG-M received funding from the European Union Horizon 2020 research and innovation program under the Marie Sklodowska- Curie grant agreement 713673 and “La Caixa” Foundation (ID 100010434), with the fellowship code being LCF/BQ/DI17/ 11620027, as well as an EMBO short-term fellowship. Research in Merida’s lab is funded by grants from the Spanish Ministry of Science and Innovation (PID2019-108357RB-100/AEI/10.13039/501100011033), and Next Generation EU (Regulation EU 2020/2094) through CSIC's Global Health Platform (PTI Salud Global) to IM."