Switching of hypertrophic signalling towards enhanced cardiomyocyte identity and maturity by a GATA4-targeted compound.

"availability of data and materials the rnaseq data are freely available in the gene expression omnibus (geo) repository ( http://www ncbi nlm nih gov/geo accession number gse186208). availability of data and materials the rnaseq data are freely available in the gene expression omnibus (geo) repository ( http://www ncbi nlm nih gov/geo accession number gse186208"

"Declarations Ethics approval and consent to participateAnimal housing and termination were conducted according the 3R principles of the EU directive 2010/63/EU governing the care and use of experimental animals and following local laws and regulations (Finnish Act on the Protection of Animals Used for Scientific or Educational Purposes [497/2013], Government Decree on the Protection of Animals Used for Scientific or Educational Purposes [564/2013]). Primary cardiac cell cultures were prepared with an internal license of the project “Lead candidates for heart failure” approved by the University of Helsinki Laboratory Animal Centre (approval number KEK20-012, May 12th, 2020). Consent for publicationNot applicable. Competing interestsSMK, MJV, MJ, JYK and HR are inventors in a patent application “Pharmaceutical compounds” (PCT/FI2017/050661). No other competing interests to disclose. Competing interests SMK, MJV, MJ, JYK and HR are inventors in a patent application “Pharmaceutical compounds” (PCT/FI2017/050661). No other competing interests to disclose."

"Funding Open Access funding provided by University of Helsinki (including Helsinki University Central Hospital). The research was funded by the Finnish Funding Agency for Innovation (Tekes, 3iRegeneration, Project 40395/13), the Academy of Finland (Projects 2666621; 321564; 328909), the Finnish Foundation for Cardiovascular Research, the Sigrid Jusélius Foundation, and the University of Helsinki Doctoral Programme for Drug Research. The funding body played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript."