Critical contribution of mitochondria in the development of cardiomyopathy linked to desmin mutation.

"rna-sequencing data that support the findings of this study have been deposited in gene expression omnibus (geo) repository with the accession codes gse245583.; rna-sequencing data that support the findings of this study have been deposited in gene expression omnibus (geo) repository with the accession codes gse245583 ( https://www ncbi nlm nih gov/geo/ )."

"Declarations Ethics approval and consent to participateAll the iPSC lines used in this study were generated from peripheral blood mononuclear cells (PBMC). Informed consent (written by Phenocell SAS (Grasse, France)) was obtained for the use of these PBMC and their derivatives for research in an anonymized way. This project (title: hiPSC4DCM) was carried out within the framework of a ministerial ethics approval that was obtained from the French Ministry for Research, Higher Education and Innovation (Name of the institutional approval committee or unit: French Ministry for Research, Higher Education and Innovation; Approval number: AC-2019-3388; Date of approval: 29 May 2019). Moreover, the post-mortem heart samples from the patients were obtained after anonymization by the Platform Center of Biological Resources of the Department of Pathology (Academic Hospital of Reims, France) (approval number: DC-2008-374). For each patient, authorizations to perform autopsy and sampling were obtained from the French Biomedicine Agency. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was supported by funds from Sorbonne Université, the CNRS, the INSERM, the Agence Nationale de la Recherche (ANR-21-CE19-0027-MoHeDis) and the AFM-Téléthon (contract number: 22142). Y.H. was supported by a Ph.D. fellowship from the AFM-Téléthon (contract number: 20479) and V.B. was supported by a Cifre PhD scholarship provided by Ksilink (Strasbourg) and supported by an ANRT grant (contract number: 2020/0074)."