Pinacidil ameliorates cardiac microvascular ischemia-reperfusion injury by inhibiting chaperone-mediated autophagy of calreticulin.

"Declarations Conflict of interestThe authors declare that they have no competing interests. Conflict of interest The authors declare that they have no competing interests."

"Funding This study was supported by the National Program on Key Basic Research Project of China (Grant No: Grant No: 2023YFC2506500, and 2023YFC2506505), National Natural Science Foundation of China (Grant No: 82300479, 82170338, 81870267, T2288101, 82200449 and 81970295), Shanghai Municipal Key Clinical Specialty (No.shslczdzk06201, shslczdzk01701), Shanghai Clinical Research Centre for Interventional Medicine (Grant No: 19MC1910300), Key Medical and Health Projects of Xiamen Province (No: 3502Z20204004), Grant of State Key Clinical Specialty Construction Project (YW2021-002), Grant of Shanghai Municipal Health Commission (2022JC012), and Grant of Zhongshan Hospital Affiliated to Fudan University (ZSLCYJ202330)."