Pasteurized <i>akkermansia muciniphila</i> improves irritable bowel syndrome-like symptoms and related behavioral disorders in mice.

"data availability statement the raw amplicon sequencing data analyzed in this study have been deposited in the embl-ebi european nucleotide archive (ena) under accession number prjeb53668 ( https://www ebi ac uk/ena/browser/view/prjeb68376 ). data availability statement the raw amplicon sequencing data analyzed in this study have been deposited in the embl-ebi european nucleotide archive (ena) under accession number prjeb53668"

"Disclosure statement P.D.C., W.M.dV. and A.B. are inventors on patent applications dealing with the use of specific bacteria and components in the treatment of different diseases. P.D.C. and W.M.dV. are co-founders of The Akkermansia Company SA. P.D.C. is co-founder of Enterosys. A.B., P.S. and W.M.dV. are employees of or associated with The Akkermansia Company. The other authors have declared no conflicting interest.."

"Author contributions: MaeM, VD, and FAC performed the experiments, analyzed the data wrote the manuscript and created the figures. GM, SG, MatM, JB, and YA performed experiments, analyzed the data, and provided technical support. SL provided technical support for calcium imaging analyses. MVH performed microbiota analysis. MB and DA critically revised the manuscript for important intellectual content, approved the drafting, and funded the project. WMdV and PS provided materials, interpreted results, critically revised the discussion, and reviewed the manuscript for important intellectual content. AB and PDC contributed to the design of the study, provided materials, and revised the manuscript. FAC designed, analyzed, supervised, funded the study, and revised the manuscript. All authors approved the final manuscript."