Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence.

"Declarations Ethics approval and consent to participateThe protocol for isolation of basal cells was approved by the Institutional Review Board (ethics committee, Nr- 34/18) of the Saarland State Medical Association and informed consent was obtained from the patients. Consent for publicationNot applicable. Competing interestsRobert Bals is the Editor-in-Chief of Respiratory Research starting from Feb 1st 2020. Competing interests Robert Bals is the Editor-in-Chief of Respiratory Research starting from Feb 1st 2020."

"Funding Open Access funding enabled and organized by Projekt DEAL. This study was supported by the German Federal Ministry of Education and Research (BMBF in the call “Alternative methods to animal experiments” (project 3-REPLACE, 16LW0140K) to CB, DY, R.B. and RM. Open Access funding enabled and organized by Projekt DEAL."