p-tau Ser356 is associated with Alzheimer's disease pathology and is lowered in brain slice cultures using the NUAK inhibitor WZ4003.

Authors:
Taylor LW; Simzer EM; Pimblett C; Lacey-Solymar OTT; McGeachan RI and 14 more

Journal:
Acta Neuropathol

Publication Year: 2024

DOI:
10.1007/s00401-023-02667-w

PMCID:
PMC10766794

PMID:
38175261

View on PubMed View on PMC View Publisher
Journal Information

Full Title: Acta Neuropathol

Abbreviation: Acta Neuropathol

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Neurology

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

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66.7% Transparent
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Evidence found in paper:

"analysis code is available on github ( https://github com/spires-jones-lab )."

Evidence found in paper:

"Declarations Conflict of interestTS-J is on the scientific advisory boards of Cognition Therapeutics and Scottish Brain Sciences. Neither had any involvement in the current work. Conflict of interest TS-J is on the scientific advisory boards of Cognition Therapeutics and Scottish Brain Sciences. Neither had any involvement in the current work."

Evidence found in paper:

"Funding This work was funded by grants awarded to Dr Claire Durrant from Race Against Dementia (ARUK-RADF-2019a-001), The James Dyson Foundation, and the Alzheimer’s Society (581 (AS-PG-21-006)) and to grants awarded to Prof Tara Spires-Jones from the UK Dementia Research Institute (UKDRI-Edin005)."

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Last Updated: Aug 05, 2025