Doxycycline for transgene control disrupts gut microbiome diversity without compromising acute neuroinflammatory response.

"raw fastq files and sample metadata for 16s sequencing were deposited at the sequence read archive (sra) ( https://www ncbi nlm nih gov/sra ) under bioproject prjna1017521.; raw and processed nanostring data were deposited at gene expression omnibus (geo) ( http://www ncbi nlm nih gov/geo/ ) under accession id gse236242.; the nanostring rna data in this study were deposited at gene expression omnibus (geo) ( http://www ncbi nlm nih gov/geo/ ) under accession id gse236242."

"Declarations Ethics approval and consent to participateAll animal work was reviewed and approved by the Baylor College of Medicine Institutional Animal Care and Use Committee. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This project was supported by NIH RF1 AG058188, RF1 AG069721-01A1, and Texas Alzheimer’s Research and Care Consortium award 2020-02-11-II to JLJ and F31 AG067676-01A1 to CAW. KLH was supported by P30 ES030285."