TrkB-mediated sustained neuroprotection is sex-specific and Erα-dependent in adult mice following neonatal hypoxia ischemia.

"Declarations Ethics approval and consent to participateAll procedures were carried out in adherence to the NIH Guide for the Care and Use of Laboratory Animals using protocols reviewed and approved by the Institutional Animal Care and Use Committee at the School of Medicine and Public Health of the University of Wisconsin-Madison, which is certified by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC). Consent for publicationAll authors give consent for publication. Competing interestsThis work was supported by R01NS111021 to Pelin Cengiz. Jon E. Levine is supported by R01DK121559-01, R21HD102172-01, and U24MH123422-01. Karyn M. Frick is supported by R01MH107886, Alzheimer’s Association ABA-22-973796, and multiple grants from the UWM Research Foundation and UWM Graduate School. Dr. Frick is a co-founder and the Chief Scientific Officer of Estrigenix Therapeutics, Inc., a company which aims to improve women's health by developing safe, clinically proven treatments for the mental and physical effects of menopause. The rest of the authors do not have any conflicts of interests to declare. Competing interests This work was supported by R01NS111021 to Pelin Cengiz. Jon E. Levine is supported by R01DK121559-01, R21HD102172-01, and U24MH123422-01. Karyn M. Frick is supported by R01MH107886, Alzheimer’s Association ABA-22-973796, and multiple grants from the UWM Research Foundation and UWM Graduate School. Dr. Frick is a co-founder and the Chief Scientific Officer of Estrigenix Therapeutics, Inc., a company which aims to improve women's health by developing safe, clinically proven treatments for the mental and physical effects of menopause. The rest of the authors do not have any conflicts of interests to declare."

"Funding This work was supported by the Department of Pediatrics Research & Development Grant (PC), NIH/NINDS R01 NS111021 (PC), NIH/NINDS K08 NS088563 (PC), NIH/NINDS 1K08NS078113 (PF), NIH Waisman Core Grant P50HD105353."