Time trends and geographical variation in major lower limb amputation related to peripheral arterial disease in England.

"Disclosure All authors have completed the ICMJE uniform disclosure form and declare funding from the National Institute for Health Research (NIHR) Programme Development Grants Programme (NIHR202042). In addition, S.W. declares that he is co-applicant and/or co-investigator on several research projects funded by the NIHR including an NIHR Senior Investigator Award (NF-SI-0617-10012); J.M. declares that he is Chair of the Vascular Society of Great Britain and Ireland Special Interest Group relating to Vascular Services, and Independent Member of the Trial Steering Committee for the UK Compass Study."

"Funding The authors would like to acknowledge funding from the National Institute for Health and Care Research (NIHR) under the Programme Development Grants Programme (NIHR202042). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care."