A viral insulin-like peptide inhibits IGF-1 receptor phosphorylation and regulates IGF1R gene expression.

"appendix a supplementary data the following are the supplementary data to this article: multimedia component 1 multimedia component 1 data availability cryoem map and atomic model of scmfrv-vilp bound to igf1r zip generated in this study have been deposited in the emdb and pdb databases respectively under the accession codes emd-41138and 8tan."

"Declaration of competing interest VG and RM are or were employees at Novo Nordisk. The other authors have no conflicts of interest to disclose related to this project."

"We would like to thank to Nancy McGilloway and Todd Gaines for their support in the Boston College Animal Care Facility. We also want to thank to Kiel Smith, the Operations Assistant of the Higgins Hall. This work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases under award number DK132674 (to EA). The work of ML, TP, LŽ and JJ was supported by the National Institute for Research of Metabolic and Cardiovascular Diseases (Program EXCELES, ID Project No. LX22NPO5104, Funded by the European Union-Next Generation EU) and by the Czech Academy of Sciences (Research Project RVO:6138963, support to the Institute of Organic Chemistry and Biochemistry). We thank Ms Mai Margetts and Dr Yibin Xu (WEHI, Parkville) for the provision of an aliquot of IGF1Rzip for use in these studies and Prof. Ken Siddle (University of Cambridge) for providing hybridomas used to express mAb 26-60 and mAb 83-7. Stable cell lines expressing receptor ectodomains were obtained from CSIRO (Parkville, Australia) by WEHI under a Technology Transfer Agreement. WEHI receives Victorian State Government Operational Infrastructure Support and funding from the Australian NHMRC Independent Research Institutes Infrastructure Support Scheme. This research used equipment funded by Australian Research Council grant (LE120100090) and (LE200100045) at the Monash Ramaciotti Centre for Cryo-Electron Microscopy, a Node of Microscopy Australia. Martina Chrudinová: Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing. Nicholas S. Kirk: Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Resources, Software. Aurelien Chuard: Data curation, Investigation. Hari Venugopal: Data curation, Formal analysis. Fa Zhang: Data curation, Formal analysis, Investigation, Methodology. Marta Lubos: Data curation, Formal analysis, Methodology. Vasily Gelfanov: Data curation, Formal analysis, Investigation. Terezie Páníková: Data curation, Formal analysis, Investigation. Lenka Žáková: Data curation, Formal analysis, Investigation, Methodology. Julianne Cutone: Data curation. Matthew Mojares: Data curation. Richard DiMarchi: Conceptualization, Funding acquisition, Supervision, Writing – original draft, Resources. Jiří Jiráček: Data curation, Formal analysis, Investigation, Methodology, Resources, Supervision, Writing – original draft. Emrah Altindis: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – original draft, Writing – review & editing."