Adoptive transfer of CMV-specific TCR-T cells for the treatment of CMV infection after haploidentical hematopoietic stem cell transplantation.

Authors:
Ma C; Chen P; Du J; Wang L; Lu N and 5 more

Journal:
J Immunother Cancer

Publication Year: 2024

DOI:
10.1136/jitc-2023-007735

PMCID:
PMC10773422

PMID:
38184303

Journal Information

Full Title: J Immunother Cancer

Abbreviation: J Immunother Cancer

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Therapeutics

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
5/6
83.3% Transparent
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Evidence found in paper:

"for each epitope the tcr with the highest cytolytic activity among the three was regarded as the top candidate tcr and was used to manufacture cmv-tcr-t cells in the clinical study 10 1136/jitc-2023-007735 supp1 supplementary data 10 1136/jitc-2023-007735 supp2 supplementary data full-length cdna sequences of tcr?"

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Evidence found in paper:

"Competing interests: None declared."

Evidence found in paper:

"Funding: This work was partially supported by grants from the National Natural Science Foundation of China (nos. 82070178, 82270162, 82270224, and 82200169), the National Key R&D Program of China (2023YFC2507800 and 2021YFA1100904), the Beijing Natural Science Foundation of China (no. 7222175), military medical support innovation and generate special program (21WQ034), Special Research Found for Health Protection (21BJZ30), and the Logistics Independent Research Program (2023hqzz09)."

Evidence found in paper:

"Trial registration number ClinicalTrials.gov Registry (NCT05140187)."

Open Access
Paper is freely available to read
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Last Updated: Aug 05, 2025