Adults with metabolically healthy overweight or obesity present more brown adipose tissue and higher thermogenesis than their metabolically unhealthy counterparts.

"Declaration of interests None."

"The study was supported by the Junta de Andalucía, Consejería de Transformación Económica, Industria, Conocimiento y Universidades Dirección General de Investigación y Transferencia del Conocimiento (ref. P18-RT-4455, ref. SOMM17/6107/UGR, and DOC 01151) and European Regional Development Funds (ERDF), the Spanish 10.13039/501100000780Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del 10.13039/501100004587Instituto de Salud Carlos III (PI13/01393), and PTA-12264, Retos de la Sociedad (DEP2016-79512-R), the Spanish Ministry of Education (FPU13/04365, FPU15/04059 and FPU19/01609), the Fundación Iberoamericana de Nutrición (FINUT), the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022), the 10.13039/100019749AstraZeneca HealthCare Foundation, the 10.13039/501100006393University of Granada Plan Propio de Investigación 2016 -Excellence actions: Unit of Excellence on Exercise and Health (UCEES). G.SD is supported by a Marie Skłodowska-Curie Actions-Individual Fellowship (101028941; Horizon 2020, European Commission). B.MT is supported by a grant for the requalification of the Spanish university system from the Ministry of Universities of the Government of Spain, funded by the 10.13039/501100000780European Union, NextGeneration EU (María Zambrano program, reference RR _C_2021_04). J.M.A.A. is supported by the Juan de la Cierva-Formación Grant FJC2020-044453-I funded by 10.13039/501100004837MCIN/10.13039/501100011033AEI/10.13039/501100011033 and “European Union NextGeneration EU/PRTR”."