Clinically relevant orthotopic pancreatic cancer models for adoptive T cell transfer therapy.

"immunosuppressive cell surface receptors lag3 and b7h4 were heightened on monocytes in kpc-luc tumors compared with those found within mt-5 tumors whereas no difference was found on ly6g + cells dcs or tams ( online supplemental figure 1b ) 10 1136/jitc-2023-008086 supp1 supplementary data 10 1136/jitc-2023-008086 supp2 supplementary data to facilitate longitudinal imaging for in vivo studies the stroma-rich mt-5 cell line was transduced to stably express luciferase (mt-5-luc)."

"Competing interests: GBL has consulted for ProDa Biotech and received compensation. GBL has also received research funding through a sponsored research agreement between Emory University and Merck and Co, Bristol-Myers Squibb, Boehringer Ingelheim, and Vaccinex. CP has received research funding through a sponsored research agreement between the Medical University of South Carolina and Obsidian, Lycera, and ThermoFisher, and is the cofounder of Ares Immunotherapy."

"Funding: This work was supported by NIH grants R01CA228406 (to GBL), R50CA233186 (to MMW), and R01CA175061, R01CA208514, and R01CA275199, plus Emory University Start-Up Funds (to CP). This work was also supported by the John Kauffman Family Professorship for Pancreatic Cancer Research (to GBL)."