Statistical analysis plan for the multicenter, open, randomized controlled clinical trial to assess the efficacy and safety of intravenous tirofiban vs aspirin in acute ischemic stroke due to tandem lesion, undergoing recanalization therapy by endovascular treatment (ATILA trial).

"Declarations Ethics approval and consent to participateThe Seville Provincial Drug Research Ethics Committee issued FAVORABLE dictum at the meeting held on February 10, 2022 (act number 03/2022). Informed consent by the patient or relatives has to be obtained before trial inclusion. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This project was funded by the Instituto de Salud Carlos III (ISCIII) through the project PI21/01322 and co-funded by the European Union. The Spanish Clinical Research Network (SCReNCode: 21.033) also contributed to the study. The ITRIBiS project (Improving Translational Research Potential at the Institute of Biomedicine of Seville) has the registration number REGPOT-2013-1. M. Medina-Rodríguez was granted a Rio Hortega contract (CM21/00096). The project was included in the Cooperative Cerebrovascular Disease Research Network (INVICTUS) (RD16/0019/0015)."

"Trial registration The trial is registered as NCT05225961. February, 7th, 2022."