Application of the Key Characteristics Framework to Identify Potential Breast Carcinogens Using Publicly Available <i>in Vivo</i>, <i>in Vitro</i>, and <i>in Silico</i> Data.

"code and input files are available on github at https://github com/silentspringinstitute/kay-et-al-ehp-2024 ."

"The authors declare no competing financial interests."

"We are grateful to Abigail Bline and Alexandre Borrel for checking code written by J.E.K. We thank Richard Judson for providing downloadable versions of the ToxValDB and eChemPortal genotoxicity databases, Lhasa Limited for providing a table of chemicals with positive or equivocal evidence for mammary tumors, Katie Paul-Friedman for assistance in processing data from ToxRefDB, and Claudia Polsky and Suzanne Fenton for reviewing and providing feedback on the manuscript. This work was supported by charitable donations to the Safer Chemicals Program at Silent Spring Institute and by the California Breast Cancer Research Program grant 23QB-1881. Silent Spring Institute is a scientific research organization dedicated to studying environmental factors in women’s health. The institute is a 501(c)3 public charity funded by federal grants and contracts, foundation grants, and private donations, including from BC organizations. Study funders had no role in study design; in the collection, analysis, and interpretation of data; in the writing of the report; and in the decision to submit the article for publication."