Accelerated prime-and-trap vaccine regimen in mice using repRNA-based CSP malaria vaccine.

"Competing interests M.A., Z.M, K.H., J.D. are full-time employees of MalarVx, Inc. M.A. and Z.M. are co-inventors on international patent PCT/US2023/19674. J.D. has equity interests in MalarVx, Inc. A.S., J.H.E., A.P.K. and S.G.R. are full-time employees of HDT Bio. A.S., J.H.E., A.P.K and S.G.R. have equity interests in HDT Bio. J.H.E has consulting agreements with various life sciences companies. J.H.E. and A.P.K. are inventors on granted U.S. patents pertaining to HDT Bio’s proprietary cationic nanocarrier formulation. S. C. M. has a patent application on selected aspects of the prime-and-trap concept through the University of Washington and has equity in a startup company (Sound Vaccines, Inc.) that is negotiating with the University of Washington for rights to this intellectual property. All other authors declare that they have no competing interests."

"In memory of Dr Anil Ghosh. We thank Tess Seltzer, Cecilia Kalhtoff, and Dr Alexis Kaushansky (Seattle Children’s Research Institute) for assistance and support of Plasmodium yoelii–infected mosquito production and dissection of the salivary glands. We thank Mint Laohajaratsang for her technical assistance and the vivarium staff of Bloodworks NW Center for assistance with the mouse facilities. This research was supported by MVX internal funds, partial HDT Bio internal funds and partial support from 1R01AI141857 (to S.C.M.)."